Genes, coagulation and cardiovascular risk
نویسندگان
چکیده
منابع مشابه
Genes and cardiovascular risk.
If DNA really is the ‘blueprint’ for life, how can genetic analysis fail to tell us what life has in store for us? One of two excellent articles in this journal shows us that the usual way to calculate risk of cardiovascular disease, such as ascertaining smoking habits and measuring blood pressure and cholesterol, is better than analyses for commonly occurring variations in DNA sequences. From ...
متن کاملGenes encoding fibrinogen and cardiovascular risk.
The role of fibrinogen in cardiovascular disease has been extensively studied, and meta-analyses have definitively confirmed that high levels of fibrinogen are associated with an increased risk of the disease. In recent years, several polymorphisms have been identified in the fibrinogen chain genes that contribute to determine the levels of fibrinogen in the general population. The fibrinogen b...
متن کاملCoagulation proteases and cardiovascular disease.
http://dx.doi.org/10.1160/TH14-09-0781 Thromb Haemost 2014; 112: 858–859 There is increasing interest in the many possible mechanisms through which coagulation proteases may promote arterial cardiovascular disease (CVD). Atherosclerosis and thrombosis are the principal pathologies underlying coronary heart disease (CHD), ischaemic stroke, and peripheral arterial disease (PAD) (1). Circulating c...
متن کاملNonsense-mediated mRNA decay among coagulation factor genes
Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. The clotting system requires precise regulation and coordinated reactions to maintain the integrity of the vasculature. Clotting insufficiency mostly occurs due to genetically inherited coagulation fact...
متن کاملThe Association between Preeclampsia and Defined Polymorphisms in Prothrombin and Coagulation Factor V Genes
Background & Aims: Preeclampsia is one of the complications of pregnancy and a major cause of maternal mortality. Since, hypercoagulation is one of the risk factors, defined polymorphisms of V and II coagulation factors (G1691A and G20210A) may increase the risk of the disease. Methods: This investigation was performed on blood samp...
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ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 2000
ISSN: 0950-9240,1476-5527
DOI: 10.1038/sj.jhh.1001021